Nodular Lymphocyte-Predominant Hodgkin’s Disease

  • Distinct from classical Hodgkin’s disease
  • Pathology shows plentiful small lymphocytes and rare Reed-Sternberg cells
  • Uncommon – <5% of Hodgkin’s disease
  • Clonal proliferation of B cells
  • Immunotype
    • JExpression of J chain
    • CD 45+
    • Epithelial membrane antigen (EMA) +
    • CD 30 –
    • CD 15 –
  • Chronic relapsing course
  • May transform into diffuse large B cell lymphoma
  • Controversial treatment
    • Watchful waiting
    • Radiotherapy for localised disease
    • Classic Hodgkin’s regimens for disseminated disease
  • Long term survival >80%
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