Diffuse Large B Cell Lymphoma

  • Most common NHL
  • 1/3 of all cases
  • Histopathological diagnosis

Presentation

  • Either primary LN site or extranodally
  • 50% have extranodal involvement at diagnosis
  • 15% have GIT involvement
  • 15% have bone marrow involvement
  • 25% of childhood NHL
  • 1/3 have B symptoms

Workup

  • Labs
    • FBC
    • LFT
      Uric acid
    • Calcium
    • QEPP
    • β2-microglobulin
  • Imaging
    • CXR
    • CT chest/abdo/pelvis
    • SPECT/PET scan
  • Bone marrow biopsy
  • LP if positive marrow

Management

  • RCHOP
  • 90% cure rate in Stage I
  • 70%  cure rate in Stage II
  •  40% will require salvage therapy
    • Long term disease free with alternate chemo <10%
    • Long-term disease free with autologous bone marrow transplant  – 40%
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s